MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases

We are thrilled to unveil the latest findings from Model Medicines in our new preprint, "MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases," now available on bioRxiv. This publication builds on our commitment to addressing unmet medical needs by using cutting-edge AI technology to discover innovative therapeutics.

Highlights of the Study

Revolutionary Antiviral Discovery

• MDL-001: Identified as a potent inhibitor targeting the Thumb pocket 1 subdomain of multiple single-stranded RNA viruses, using our proprietary AI drug discovery platform, GALILEO™.

• Broad-Spectrum Activity: Demonstrated significant in vitro efficacy against a variety of pathogenic RNA viruses, underscoring its potential as a universal antiviral treatment.

Clinical Potential of MDL-001

• Preclinical and Clinical Studies: MDL-001 exhibited potent in vivo efficacy in a mouse model of SARS-CoV-2 infection, achieving notable viral load reductions.

• Safety and Tolerability: Clinical trials confirmed that orally administered MDL-001 is both safe and well-tolerated, paving the way for further development as a promising broad-spectrum antiviral candidate.

Cutting-Edge AI Innovation

• GALILEO™ and ChemPrint™: Our advanced computational pipeline combines bioinformatics with the geometric deep learning algorithm ChemPrint™ to identify novel drug candidates. These tools enable accelerated drug discovery, high hit rates, and exploration of new chemical spaces.

• Chemical Repositioning Library: Leveraging a vast library of compounds, GALILEO™ enabled the discovery of MDL-001 with unprecedented efficiency.

Addressing Pandemic Preparedness

• Global Health Impact: The emergence of MDL-001 as a broad-spectrum antiviral enhances global pandemic preparedness by offering a robust therapeutic option against current and future viral outbreaks.

• Strategic Relevance: Safe and effective broad-spectrum antivirals like MDL-001 are crucial for strengthening national security, minimizing the health and economic impact of viral pandemics, and empowering public health organizations to combat outbreaks rapidly.